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pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers raise fee of toremifene metabolism, lowering the continual-condition concentration in serum.pentobarbital will reduce the level or effect of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism